Dietler, M in The Oxford Handbook of the Archaeology of Ritual and Religion (ed. Insoll, T.) Ch. 13 (Oxford Academic, 2012) .
Wheless, J. W. History of the ketogenic diet. Epilepsia 49, 3–5 (2008).
Google Scholar
Longo, V. D. & Mattson, M. P. Fasting: molecular mechanisms and clinical applications. Cell Metab. 19, 181–192 (2014).
Google Scholar
de Cabo, R. & Mattson, M. P. Effects of intermittent fasting on health, aging, and disease. N. Engl. J. Med. 381, 2541–2551 (2019).
Google Scholar
Hofer, S. J., Carmona-Gutierrez, D., Mueller, M. I. & Madeo, F. The ups and downs of caloric restriction and fasting: from molecular effects to clinical application. EMBO Mol. Med. 14, e14418 (2022).
Google Scholar
Varady, K. A., Cienfuegos, S., Ezpeleta, M. & Gabel, K. Clinical application of intermittent fasting for weight loss: progress and future directions. Nat. Rev. Endocrinol. 18, 309–321 (2022).
Google Scholar
Dmitrieva-Posocco, O. et al. β-Hydroxybutyrate suppresses colorectal cancer. Nature 605, 160–165 (2022).
Google Scholar
de Groot, S. et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat. Commun. 11, 1–9 (2020).
Google Scholar
Nencioni, A., Caffa, I., Cortellino, S. & Longo, V. D. Fasting and cancer: molecular mechanisms and clinical application. Nat. Rev. Cancer 18, 707–719 (2018).
Google Scholar
Steinhauser, M. L. et al. The circulating metabolome of human starvation. JCI Insight 3, e121434 (2018).
Google Scholar
Pietzner, M. et al. Mapping the proteo-genomic convergence of human diseases. Science 374, eabj1541 (2021).
Google Scholar
Koprulu, M. et al. Proteogenomic links to human metabolic diseases. Nat. Metab. 5, 516–528 (2023).
Google Scholar
Ferkingstad, E. et al. Large-scale integration of the plasma proteome with genetics and disease. Nat. Genet. (2021).
Google Scholar
Sun, B. B. et al. Genomic atlas of the human plasma proteome. Nature 558, 73–79 (2018).
Google Scholar
Suhre, K. et al. Connecting genetic risk to disease end points through the human blood plasma proteome. Nat. Commun. 8, 14357 (2017).
Google Scholar
Templeman, I. et al. A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults. Sci. Transl. Med. 13, 1–16 (2021).
Google Scholar
Schroor, M. M., Joris, P. J., Plat, J. & Mensink, R. P. Effects of intermittent energy restriction compared to those of continuous energy restriction on body composition and cardiometabolic risk markers—a systematic review and meta-analysis of randomized controlled trials in adults. Adv. Nutr. (2023).
Google Scholar
Allaf, M. et al. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst. Rev. 1, CD013496 (2021).
Google Scholar
Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G. & Shulman, G. I. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 254, 573–576 (1991).
Google Scholar
Ogłodek, E. & Pilis Prof, W. Is water-only fasting safe? Glob. Adv. Health Med. 10, 21649561211031178 (2021).
Google Scholar
Patel, S. et al. GDF15 provides an endocrine signal of nutritional stress in mice and humans. Cell Metab. 29, 707–718.e8 (2019).
Google Scholar
Uhlén, M. et al. Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015).
Google Scholar
Muranen, T. et al. Starved epithelial cells uptake extracellular matrix for survival. Nat. Commun. 8, 1–12 (2017).
Google Scholar
Jiang, Z. et al. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metab. 33, 1836–1852.e11 (2021).
Google Scholar
Yamazaki, T. et al. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. J. Cell Sci. 122, 243–255 (2009).
Google Scholar
Prokopovic, V. et al. Isolation, biochemical characterization and anti-bacterial activity of BPIFA2 protein. Arch. Oral. Biol. 59, 302–309 (2014).
Google Scholar
Meex, R. C. et al. Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism. Cell Metab. 22, 1078–1089 (2015).
Google Scholar
Lee, N. J. et al. Osteoglycin, a novel coordinator of bone and glucose homeostasis. Mol. Metab. 13, 30–44 (2018).
Google Scholar
Puchalska, P. & Crawford, P. A. Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab. 25, 262–284 (2017).
Google Scholar
Morawski, M. et al. Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan. Philos. Trans. R. Soc. B 369, 20140046 (2014).
Google Scholar
Lau, L. W., Cua, R., Keough, M. B., Haylock-Jacobs, S. & Yong, V. W. Pathophysiology of the brain extracellular matrix: a new target for remyelination. Nat. Rev. Neurosci. 14, 722–729 (2013).
Google Scholar
Dankovich, T. M. et al. Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R. Nat. Commun. 12, 1–23 (2021).
Google Scholar
Rogawski, M. A., Löscher, W. & Rho, J. M. Mechanisms of action of antiseizure drugs and the ketogenic diet. Cold Spring Harb. Perspect. Med. 6, 28 (2016).
Google Scholar
COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19. Nature 608, E1–E10 (2022).
Google Scholar
Gregory, S. G. et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat. Genet. 39, 1083–1091 (2007).
Google Scholar
Valette, K. et al. Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank. Commun. Biol. 4, 700 (2021).
Google Scholar
Stefan, N., Birkenfeld, A. L. & Schulze, M. B. Global pandemics interconnected—obesity, impaired metabolic health and COVID-19. Nat. Rev. Endocrinol. 17, 135–149 (2021).
Google Scholar
Thompson, A. J., Baranzini, S. E., Geurts, J., Hemmer, B. & Ciccarelli, O. Multiple sclerosis. Lancet 391, 1622–1636 (2018).
Google Scholar
Pietzner, M. et al. Synergistic insights into human health from aptamer- and antibody-based proteomic profiling. Nat. Commun. 12, 6822 (2021).
Google Scholar
Pietzner, M. et al. ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19. Nat. Commun. 13, 4484 (2022).
Google Scholar
Susan-Resiga, D. et al. Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin. J. Biol. Chem. 297, 101177 (2021).
Google Scholar
Bloise, E. et al. Activin A in mammalian physiology. Physiol. Rev. 99, 739–780 (2019).
Google Scholar
Ha, E., Bae, S. C. & Kim, K. Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci. Ann. Rheum. Dis. 80, 558–565 (2021).
Google Scholar
Kwon, Y. C. et al. Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis. Ann. Rheum. Dis. 79, 1438–1445 (2020).
Google Scholar
Philippou, E., Petersson, S. D., Rodomar, C. & Nikiphorou, E. Rheumatoid arthritis and dietary interventions: systematic review of clinical trials. Nutr. Rev. 79, 410–428 (2021).
Google Scholar
Howson, J. M. M. et al. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat. Genet. 49, 1113–1119 (2017).
Google Scholar
Kuwabara, K. et al. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain. J. Biol. Chem. 271, 5025–5032 (1996).
Google Scholar
Wilhelmi de Toledo, F., Grundler, F., Bergouignan, A., Drinda, S. & Michalsen, A. Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects. PLoS ONE 14, e0209353 (2019).
Google Scholar
Mindikoglu, A. L. et al. Intermittent fasting from dawn to sunset for four consecutive weeks induces anticancer serum proteome response and improves metabolic syndrome. Sci. Rep. 10, 1–14 (2020).
Google Scholar
Geyer, P. E. et al. Proteomics reveals the effects of sustained weight loss on the human plasma proteome. Mol. Syst. Biol. 12, 901 (2016).
Google Scholar
Rustad, P. I. et al. Intake of protein plus carbohydrate during the first two hours after exhaustive cycling improves performance the following day. PLoS ONE 11, e0153229 (2016).
Google Scholar
Kjeldahl, J. Neue Methode zur Bestimmung des Stickstoffs in organischen Körpern. Z. Anal. Chem. 22, 366–382 (1883).
Google Scholar
Zhong, W. et al. Next generation plasma proteome profiling to monitor health and disease. Nat. Commun. 12, 2493 (2021).
Google Scholar
Assarsson, E. et al. Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLoS ONE 9, e95192 (2014).
Google Scholar
Systemic proteome adaptions to 7-day complete caloric restriction in humans. Zenodo (2024)
Kuznetsova, A., Brockhoff, P. B. & Christensen, R. H. B. lmerTest package: tests in linear mixed effects models. J. Stat. Softw. 82, 1–26 (2017).
Google Scholar
Kolberg, L., Raudvere, U., Kuzmin, I., Vilo, J. & Peterson, H. gprofiler2—an R package for gene list functional enrichment analysis and namespace conversion toolset g:Profiler. F1000Research 9, 1–27 (2020).
Google Scholar
Kanehisa, M. & Goto, S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27–30 (2000).
Google Scholar
Grant, A. J., Gill, D., Kirk, P. D. W. & Burgess, S. Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity. PLoS Genet. 18, e1009975 (2022).
Google Scholar
Wang, G., Sarkar, A., Carbonetto, P. & Stephens, M. A simple new approach to variable selection in regression, with application to genetic fine mapping. J. R. Stat. Soc. Ser. B (2020).
Google Scholar
Wallace, C. A more accurate method for colocalisation analysis allowing for multiple causal variants. PLoS Genet. 17, e1009440 (2021).
Google Scholar
Elsworth, B. et al. The MRC IEU OpenGWAS data infrastructure. Preprint at bioRxiv (2020).